The Cherokee Round up that you reference happened in 1838 (200 years after the end of my statistic). I agree that there was systemic genocide, physical and cultural, but 90% of the indigenous population of North America died before those policies even started

While this person may have planned on using small pox blankets, what the original commenter, and the person you responded too are talking about is the fact that 55 million Native American died between 1492-1600. This introduction of disease was largely accidental